Bill Chiu Selected Research

Silk

1/2021	Development of a dinutuximab delivery system using silk foams for GD2 targeted neuroblastoma cell death.
1/2020	Local delivery of dinutuximab from lyophilized silk fibroin foams for treatment of an orthotopic neuroblastoma model.
1/2020	Enhancing sustained-release local therapy: Single versus dual chemotherapy for the treatment of neuroblastoma.
12/2019	Replicating and identifying large cell neuroblastoma using high-dose intra-tumoral chemotherapy and automated digital analysis.
6/2019	Down-regulation of MYCN protein by CX-5461 leads to neuroblastoma tumor growth suppression.
1/2019	Silk Reservoirs for Local Delivery of Cisplatin for Neuroblastoma Treatment: In Vitro and In Vivo Evaluations.
10/2018	In vitro and in vivo evaluation of etoposide - silk wafers for neuroblastoma treatment.
10/2018	Disseminated injection of vincristine-loaded silk gel improves the suppression of neuroblastoma tumor growth.
12/2017	Manipulation of variables in local controlled release vincristine treatment in neuroblastoma.
2/2017	Implantable chemotherapy-loaded silk protein materials for neuroblastoma treatment.

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Bill Chiu Research Topics

Disease

20	Neuroblastoma 07/2021 - 10/2006
20	Neoplasms (Cancer) 07/2021 - 01/2016
3	Necrosis 01/2020 - 10/2018
2	Hypertrophy 01/2021 - 06/2019
2	Pain (Aches) 01/2021 - 01/2020
2	Primary Hyperparathyroidism 08/2008 - 05/2006
2	Portal Hypertension 10/2007 - 06/2006
1	Cardiotoxicity 01/2018
1	Glioma (Gliomas) 01/2017
1	Ewing Sarcoma (Sarcoma, Ewing) 12/2016
1	Sarcoma (Soft Tissue Sarcoma) 12/2016
1	Gastroschisis 07/2015
1	Familial duodenal atresia 01/2014
1	Esophageal Atresia 01/2014
1	Tracheoesophageal Fistula 01/2014
1	Esophageal atresia with or without tracheoesophageal fistula 01/2014
1	Hemorrhage 06/2006
1	Esophageal and Gastric Varices (Esophageal Varices) 06/2006
1	Hypersplenism (Anemia, Splenic) 06/2006
1	Brain Diseases (Brain Disorder) 06/2006
1	Chronic Pancreatitis 05/2006
1	Patent Ductus Arteriosus 01/2006
1	Pneumoperitoneum 01/2006
1	Intestinal Perforation 01/2006
1	Necrotizing Enterocolitis 01/2006
1	Cysts 12/2005

Drug/Important Bio-Agent (IBA)

12	Silk FDA Link 01/2021 - 07/2015
7	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2020 - 03/2007
6	Pharmaceutical PreparationsIBA 01/2020 - 07/2015
5	Vincristine (Oncovin)FDA LinkGeneric 01/2020 - 12/2016
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2017
3	N-Myc Proto-Oncogene ProteinIBA 01/2021 - 01/2018
3	Epidermal Growth Factor (EGF)IBA 08/2007 - 10/2006
2	dinutuximabIBA 01/2021 - 01/2020
2	Fibroins (Fibroin)IBA 01/2020 - 02/2017
2	Etoposide (VP 16)FDA LinkGeneric 01/2020 - 10/2018
2	Cisplatin (Platino)FDA LinkGeneric 01/2020 - 01/2019
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 07/2021
1	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2020
1	AZD5153IBA 01/2020
1	ChromatinIBA 01/2020
1	BuffersIBA 01/2020
1	Biocompatible Materials (Biomaterials)IBA 01/2020
1	Monoclonal AntibodiesIBA 01/2020
1	RNA (Ribonucleic Acid)IBA 01/2020
1	Immunoglobulin G (IgG)IBA 01/2020
1	dinaciclibIBA 01/2020
1	CX 5461IBA 06/2019
1	Indocyanine Green (Cardio-Green)FDA LinkGeneric 12/2018
1	Capsules (Microcapsules)IBA 12/2018
1	GelsIBA 10/2018
1	Dexrazoxane (Zinecard)FDA LinkGeneric 01/2018
1	AnthracyclinesIBA 01/2018
1	Cardiotonic Agents (Cardiac Stimulants)IBA 01/2018
1	Phosphatidylinositols (Phosphatidylinositol)IBA 11/2017
1	Small Interfering RNA (siRNA)IBA 11/2017
1	intersectin 1IBA 11/2017
1	Eosine Yellowish-(YS) (Eosin)IBA 01/2016
1	Hematoxylin (Haematoxylon)IBA 01/2016
1	CrizotinibIBA 07/2015
1	Phosphotransferases (Kinase)IBA 07/2015
1	Parathyroid Hormone (Parathormone)IBA 08/2008
1	Caspase 3 (Caspase-3)IBA 08/2007
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 03/2007
1	Tuberculin (PPD)IBA 01/2006
1	Radioisotopes (Radionuclides)IBA 12/2005

Therapy/Procedure

10	Drug Therapy (Chemotherapy) 01/2020 - 07/2015
6	Therapeutics 07/2021 - 07/2015
2	Immunotherapy 01/2021 - 01/2020
2	Parathyroidectomy 08/2008 - 05/2006
1	Lasers (Laser) 12/2018
1	Enteral Nutrition (Feeding, Tube) 07/2015
1	Gastrostomy 01/2014
1	Transplantation 10/2007
1	Surgical Portasystemic Shunt (Portosystemic Shunt) 06/2006
1	Surgical Splenorenal Shunt (Splenorenal Shunt) 06/2006
1	Pancreaticojejunostomy 05/2006
1	Laparotomy 01/2006
1	Jejunostomy 12/2005